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It was approved in the uk in 1963 as ponstan , in west germany in 1964 as ponalar , and in france as ponstyl and the us in 1967 as ponstel .

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Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusionIn these patientsadministration of an NSAID may cause a dose-dependent reduction in prostaglandin formation andsecondarilyin renal blood flowwhich may precipitate overt renal decompensationPatients at greatest risk of this reaction are those with impaired renal functiondehydrationhypovolemiaheart failureliver dysfunctionthose taking diuretics and ACE inhibitors or ARBsand the elderlyDiscontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.

Mefenamic acid is used to treat pain or inflammation caused by arthritisIt is also used to treat menstrual pain.

Before using this medicationwomen of childbearing age should talk with their doctor(sabout the benefits and riskssuch as miscarriagetrouble getting pregnantTell your doctor if you are pregnant or if you plan to become pregnantDuring pregnancythis medication should be used only when clearly neededIt is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

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